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The approach to power analysis is\nsimulation-based, running the analysis many times on simulated\ndata and estimating empirical power. This method can be used to\nestablish a minimum sample size required to achieve a given\ntarget power. The package also includes functions for more\ngeneral power and sample size calculation, including\npresence/absence and margin of error based approaches.", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "LazyData": "true", "LazyDataCompression": "xz", "RoxygenNote": "7.3.2", "BugReports": "https://github.com/mrc-ide/DRpower/issues", "Config/testthat/edition": "3", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "libicu-dev", "Repository": "https://plasmogenepi.r-universe.dev", "Date/Publication": "2025-07-24 12:48:17 UTC", "RemoteUrl": "https://github.com/mrc-ide/DRpower", "RemoteRef": "HEAD", "RemoteSha": "133243fdbef1b964e8a2542d7ca2811c29676c18", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-20 08:50:29 UTC", "User": "root" }, "Author": "Bob Verity [aut, cre],\nShazia Ruybal [aut]", "Maintainer": "Bob Verity ", "MD5sum": "b06b573d8bf67d9cab646450448bd178", "_user": "plasmogenepi", "_type": "src", "_file": "DRpower_1.0.4.tar.gz", "_fileid": 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Estimate prevalence", "2. Compare prevalence against a threshold", "3. Estimate the ICC" ], "created": "2023-05-25 16:05:03", "modified": "2023-11-30 23:30:10", "commits": 4 }, { "source": "rationale1_background.Rmd", "filename": "rationale1_background.html", "title": "Background", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "What are pfhrp2/3 deletions?", "What are we doing about it?", "What does the 2020 Master Protocol recommend?", "How does the DRpower method fit in?", "Defining our terms" ], "created": "2023-05-25 16:05:03", "modified": "2023-11-30 23:30:10", "commits": 5 }, { "source": "rationale2_issue.Rmd", "filename": "rationale2_issue.html", "title": "CIs and Overdispersion", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "2. Why is this a tricky problem?", "2.1 Dealing with overdispersion" ], "created": "2023-05-25 16:05:03", "modified": "2023-11-30 23:30:10", "commits": 5 }, { "source": "tutorial_design.Rmd", "filename": "tutorial_design.html", "title": "Designing a study", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "1. Consult sample size tables", "2. Consult power curves", "3. Refine sample sizes", "4. Account for dropout", "5. Iterate and improve", "6. Detecting rare variants (bonus section)", "7. Controling the margin of error (bonus section)" ], "created": "2023-05-25 16:05:03", "modified": "2025-07-24 12:42:05", "commits": 8 }, { "source": "historical_analysis.Rmd", "filename": "historical_analysis.html", "title": "Historical analysis", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "1. Available data on pfhrp2/3 deletions", "2. 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The Bayesian hierarchical model" ], "created": "2023-07-25 14:37:10", "modified": "2025-07-24 12:42:05", "commits": 5 }, { "source": "rationale8_power.Rmd", "filename": "rationale8_power.html", "title": "Power and Sample Size in the DRpower Model", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "8. Estimating power via simulation", "8.1. Sample size calculation", "8.2. How to choose final sample sizes" ], "created": "2023-07-25 14:37:10", "modified": "2023-12-10 14:15:17", "commits": 5 }, { "source": "rationale6_master_protocol.Rmd", "filename": "rationale6_master_protocol.html", "title": "Sample Size Calculation in the 2020 WHO Master Protocol", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "6. The 2020 WHO Master Protocol", "6.1. The logic behind the sample size calculation", "6.2. Working through the updated protocol numbers", "6.3. Issues with the approach", "References" ], "created": "2023-07-25 14:37:10", "modified": "2023-11-30 23:30:10", "commits": 4 }, { "source": "rationale3_design_effect.Rmd", "filename": "rationale3_design_effect.html", "title": "The Design Effect", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "3. What is the design effect?", "3.1 The effective sample size", "3.2 Relating $D_{eff}$ to the ICC" ], "created": "2023-05-25 16:05:03", "modified": "2023-11-30 23:30:10", "commits": 5 }, { "source": "rationale5_bayesian.Rmd", "filename": "rationale5_bayesian.html", "title": "The DRpower model", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "5. A Bayesian approach" ], "created": "2023-07-25 14:37:10", "modified": "2025-07-24 12:42:05", "commits": 5 }, { "source": "rationale7_ztest.Rmd", "filename": "rationale7_ztest.html", "title": "The One-sample Z-test", "author": "Bob Verity", "engine": "knitr::knitr", "headings": [ "7. 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